Of course no superhero campaign would be complete without some evil organizations hell-bent on world domination. Here is a few of the major villainous organizations in the campaign world...
Villainous Infamy Legion Embodied (VILE): A global organization bent on world domination. They utilize superhumans and human henchmen for their plans. They primarily seek global domination through subterfuge and secret manipulation but have been known to conduct larger acts of terrorism. It is rumored that a council of seven superbeings run the organization.
Medusa: Another global criminal organization, Medusa is more bent on consolidating power and gaining financial wealth than that of VILE. They primarily use human henchmen and automatons for their operations, but are also known to have superhumans in their ranks.
New Aryan Dawn Society (NADS): A combination of technological and occult powered villains out of South America seeking to further the Fourth Reich. Some claim that the organization is run by former Nazis that managed to escape Germany at the end of WW2, and were somehow able to prolong their life. NADS is also rampant on pushing an anti-mutant agenda through secretly supporting political candidates and parties that embrace this platform. They see mutants not only impure, but also possibly a hindrance to their efforts to establish a new world Nazi order.
Damage Incorporated: A loose organization of superbeings that act strictly as mercenaries. They are hired by groups like NADS, Medusa, and the Black Hand. Damage Inc. has also been hired by terrorist organizations, dictators, and even some industrialized nations for covert operations.
The Black Hand: A supernatural organization based primarily out of Asia. They not only use superbeings, but also have several henchmen extensively trained in the martial arts. Their main goal is power and influence, but some suspect they also seek to gain control of supernatural artifacts, which place them in competition with the Shadow Legion.
The Shadow Legion: Another supernatural organization that is typically at odds with the Talisman. They derive from an ancient society. Many believe a council of 13 runs the group, with some of the council members rumored to be nearly 200 years old. Others that are exceedingly knowledgeable about the Shadow Legion claim the group is really run by demons (or beings from other dimensions). They are set upon opening a rift in time and space to allow more of their kind through in order to dominate Earth.
The Toymakers: A group which utilizes primarily technological, but sometimes magical, means to create super powered weaponry and equipment. They sell their services to the highest bidder and actively attempt to thwart any competition (typically research from MISS and ASTRO). They have even been known to interfere with research and development of other criminal organizations. In some aspects they are after global technological domination of all research for Earth, but are willing to sell their services for the right price.
The Shop: A secret government agency created during World War II to counter the Nazi’s superhero research efforts. They have morphed from a secret branch of United States intelligence agencies to that of a super secret federal group that answers to no one. They actively pull strings in both the NSA and CIA, and even with other foreign intelligence agencies. Another aspect of their work is actively recruiting superbeings to work as covert agents, particularly mutants. The power of this organization is immense. The group has nearly an Illuminati status, with both intelligence and criminal organizations not knowing of its existence.
Mutant Liberation Army (MLA): A very small mutant terrorist group. They are active in using violence to promote the mutant cause, typically by acting against political groups seeking to implement policies that would control, or monitor, superhumans in the general public.
[It is rumored that some of the leaders were assassins employed by the Shop. This may suggest why their efforts have been directed against the Shop and NADS in the past.]